This module contains 14 genes including ACKR3, MECOM, GATA6, SLC1A1, and OTX2, with enrichment in endoderm development, chemokine signaling, and transcriptional regulation. Knockdown of SOX17, EOMESODERMIN, and FOXA2 activates this module. Knockdown of POU5F1, NANOG, and OCT4 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.