This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for CDKN1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDKN1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDKN1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,349,790–12,350,566 | 367.1 kb | Distal (>10kb) Multiome HiCAR | 671 | |
| chr12:12,356,841–12,357,808 | 360.2 kb | Distal (>10kb) Multiome HiCAR | 912 | |
| chr12:12,561,525–12,563,261 | 154.6 kb | Distal (>10kb) Multiome | 768 | |
| chr12:12,611,502–12,612,657 | 105.5 kb | Distal (>10kb) Multiome | 980 | |
| chr12:12,684,299–12,685,064 | 32.6 kb | Distal (>10kb) Multiome | 306 | |
| chr12:12,693,129–12,694,039 | 23.8 kb | Distal (>10kb) Multiome | 190 | |
| chr12:12,695,955–12,697,008 | 21.0 kb | Distal (>10kb) Multiome | 568 | |
| chr12:12,704,663–12,704,918 | 8.3 kb | Proximal (<10kb) | 461 | |
| chr12:12,716,729–12,717,910 | 131 bp | At TSS Multiome | 799 | |
| chr12:12,723,708–12,726,164 | 8.2 kb | Proximal (<10kb) Multiome | 958 | |
| chr12:12,742,773–12,743,975 | 25.9 kb | Distal (>10kb) Multiome | 118 | |
| chr12:12,775,741–12,776,742 | 59.0 kb | Distal (>10kb) Multiome | 267 | |
| chr12:12,786,507–12,787,490 | 69.6 kb | Distal (>10kb) Multiome | 739 | |
| chr12:12,799,298–12,799,907 | 82.3 kb | Distal (>10kb) Multiome | 137 | |
| chr12:12,812,936–12,813,661 | 95.9 kb | Distal (>10kb) Multiome | 700 | |
| chr12:12,890,573–12,891,789 | 173.5 kb | Distal (>10kb) Multiome | 656 | |
| chr12:12,999,403–13,001,860 | 283.0 kb | Distal (>10kb) Multiome | 719 |
Genomic view of the CDKN1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.