This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NECTIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NECTIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NECTIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,643,571–44,644,620 | 202.4 kb | Distal (>10kb) Multiome | 710 | |
| chr19:44,747,085–44,747,789 | 98.7 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,757,112–44,758,480 | 88.9 kb | Distal (>10kb) Multiome | 209 | |
| chr19:44,758,633–44,759,104 | 87.4 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 75.5 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 68.4 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 45.7 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 38.2 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 1.5 kb | Proximal (<10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 44.6 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 57.5 kb | Distal (>10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 60.4 kb | Distal (>10kb) Multiome | 645 | |
| chr19:44,913,546–44,915,671 | 68.9 kb | Distal (>10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 80.9 kb | Distal (>10kb) Multiome | 277 | |
| chr19:44,954,641–44,955,824 | 108.9 kb | Distal (>10kb) Multiome | 835 | |
| chr19:45,001,031–45,002,639 | 155.1 kb | Distal (>10kb) Multiome | 694 | |
| chr19:45,038,879–45,039,566 | 192.8 kb | Distal (>10kb) Multiome | 800 | |
| chr19:45,075,125–45,076,814 | 230.2 kb | Distal (>10kb) Multiome | 710 | |
| chr19:45,078,897–45,080,647 | 233.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:45,091,042–45,093,574 | 246.7 kb | Distal (>10kb) Multiome | 959 |
Genomic view of the NECTIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.