DAPK3

death associated protein kinase 3 | ZIP, ZIPK

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.25 Developmental clusters: GC7

Biological processes 61 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)PML body (GO:0016605)apoptotic process (GO:0006915)apoptotic process (GO:0006915)apoptotic process (GO:0006915)cAMP response element binding protein binding (GO:0008140)cellular response to type II interferon (GO:0071346)cellular response to type II interferon (GO:0071346)centrosome (GO:0005813)chromosome, centromeric region (GO:0000775)chromosome, centromeric region (GO:0000775)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)identical protein binding (GO:0042802)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)leucine zipper domain binding (GO:0043522)midbody (GO:0030496)midbody (GO:0030496)negative regulation of translation (GO:0017148)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of canonical Wnt signaling pathway (GO:0090263)positive regulation of cell migration (GO:0030335)protein autophosphorylation (GO:0046777)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of DNA-templated transcription (GO:0006355)regulation of actin cytoskeleton organization (GO:0032956)regulation of actin cytoskeleton organization (GO:0032956)regulation of apoptotic process (GO:0042981)regulation of apoptotic process (GO:0042981)regulation of autophagy (GO:0010506)regulation of autophagy (GO:0010506)regulation of cell motility (GO:2000145)regulation of cell shape (GO:0008360)regulation of focal adhesion assembly (GO:0051893)regulation of mitotic cell cycle (GO:0007346)regulation of mitotic nuclear division (GO:0007088)regulation of myosin II filament organization (GO:0043519)regulation of smooth muscle contraction (GO:0006940)small GTPase binding (GO:0031267)spindle (GO:0005819)spindle (GO:0005819)

Expression (TPM)

TFs regulating DAPK3 0 TFs

Transcription factors with Perturb-seq knockdown data for DAPK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAPK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to DAPK3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAPK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:3,699,968–3,700,899	270.6 kb	Distal (>10kb) Multiome	489
chr19:3,721,462–3,721,997	249.5 kb	Distal (>10kb) Multiome	760
chr19:3,722,652–3,723,093	248.2 kb	Distal (>10kb) Multiome	106
chr19:3,761,103–3,762,150	209.5 kb	Distal (>10kb) Multiome	839
chr19:3,762,300–3,763,344	208.2 kb	Distal (>10kb) Multiome	817
chr19:3,786,012–3,786,456	184.9 kb	Distal (>10kb) Multiome	237
chr19:3,868,451–3,869,181	102.1 kb	Distal (>10kb) Multiome	233
chr19:3,932,937–3,933,664	37.8 kb	Distal (>10kb) Multiome	198
chr19:3,968,623–3,969,280	2.3 kb	Proximal (<10kb) Multiome	547
chr19:3,969,432–3,970,090	at TSS	At TSS	290
chr19:3,970,535–3,971,713	95 bp	At TSS Multiome	728
chr19:3,985,032–3,985,862	14.3 kb	Distal (>10kb) Multiome	932
chr19:3,987,682–3,988,217	16.9 kb	Distal (>10kb) Multiome	346
chr19:4,006,992–4,008,553	36.4 kb	Distal (>10kb) Multiome	888
chr19:4,064,058–4,067,782	94.8 kb	Distal (>10kb) Multiome	811
chr19:4,123,681–4,124,581	153.0 kb	Distal (>10kb) Multiome	798
chr19:4,182,102–4,182,890	211.4 kb	Distal (>10kb) Multiome	862
chr19:4,198,066–4,198,600	227.2 kb	Distal (>10kb) Multiome	214
chr19:4,246,623–4,247,617	276.2 kb	Distal (>10kb) Multiome	960

Genome Browser

Genomic view of the DAPK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.