This 34-gene module, containing NPPB, CCN2, NFKBIA, WFDC2, and EIF4EBP1, is enriched for genes involved in actin cytoskeleton organization, actin filament-based processes, and focal adhesion. Knockdown of SMAD5 activates this module. No repressing transcription factors were identified for this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.