DE-4 ›

DE-4.26

Submodule 11 genes

Cytoskeletal organization and focal adhesion dynamics

This 11-gene module includes PIK3CB, VCL, EDA, FLNB, and AKAP13, with top enrichment in cytoskeleton organization, focal adhesion, and cell-substrate adhesion. Knockdown of GATA4 activates this module, while knockdown of SOX17, OTX2, and FOXA2 repress it. These results suggest this module coordinates structural and adhesive processes during endoderm differentiation.

Key terms: homotypic cell-cell adhesion cell-cell adhesion regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction Notable genes: PIK3CB VCL EDA FLNB AKAP13 GPR39 LPP ADAM19

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

| |
Low
High z
Huangfu Lab · Publications · Resources · Contact