Enables several functions, including phosphatidylinositol-3,4,5-trisphosphate binding activity; protein serine/threonine kinase binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cellular component biogenesis; and positive regulation of intracellular signal transduction. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in several cellular components, including adherens junction; cytoplasmic side of plasma membrane; and focal adhesion. Biomarker of acute myeloid leukemia. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FERMT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FERMT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FERMT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,694,713–52,696,105 | 255.3 kb | Distal (>10kb) Multiome | 749 | |
| chr14:52,706,745–52,707,707 | 243.9 kb | Distal (>10kb) Multiome | 713 | |
| chr14:52,729,614–52,730,927 | 221.0 kb | Distal (>10kb) Multiome | 803 | |
| chr14:52,790,881–52,792,384 | 159.4 kb | Distal (>10kb) Multiome HiCAR | 1077 | |
| chr14:52,827,263–52,828,172 | 123.4 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr14:52,835,079–52,835,883 | 115.7 kb | Distal (>10kb) Multiome | 369 | |
| chr14:52,852,332–52,854,201 | 97.8 kb | Distal (>10kb) Multiome | 475 | |
| chr14:52,950,305–52,952,252 | 172 bp | At TSS Multiome | 746 | |
| chr14:52,954,374–52,954,865 | 3.3 kb | Proximal (<10kb) | 198 | |
| chr14:53,151,675–53,153,814 | 202.3 kb | Distal (>10kb) Multiome | 835 | |
| chr14:53,180,073–53,181,385 | 230.0 kb | Distal (>10kb) Multiome | 192 | |
| chr14:53,217,268–53,218,117 | 266.6 kb | Distal (>10kb) Multiome | 507 |
Genomic view of the FERMT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.