The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for MECOM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MECOM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MECOM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:169,146,906–169,147,932 | 516.1 kb | Distal (>10kb) Multiome HiCAR | 531 | |
| chr3:169,148,563–169,149,734 | 514.2 kb | Distal (>10kb) Multiome HiCAR | 542 | |
| chr3:169,509,784–169,511,185 | 153.0 kb | Distal (>10kb) Multiome | 338 | |
| chr3:169,658,211–169,659,014 | 4.8 kb | Proximal (<10kb) Multiome | 212 | |
| chr3:169,659,140–169,659,422 | 4.2 kb | Proximal (<10kb) | 83 | |
| chr3:169,659,802–169,660,214 | 3.4 kb | Proximal (<10kb) | 112 | |
| chr3:169,661,423–169,664,653 | 9 bp | At TSS Multiome | 840 | |
| chr3:169,666,181–169,666,315 | 2.6 kb | Proximal (<10kb) | 28 | |
| chr3:169,666,499–169,666,980 | 2.9 kb | Proximal (<10kb) | 110 | |
| chr3:169,668,169–169,669,789 | 5.6 kb | Proximal (<10kb) Multiome | 655 | |
| chr3:169,764,381–169,765,564 | 101.5 kb | Distal (>10kb) Multiome | 782 | |
| chr3:169,769,273–169,770,082 | 106.0 kb | Distal (>10kb) Multiome | 566 | |
| chr3:169,771,800–169,773,839 | 108.4 kb | Distal (>10kb) Multiome | 1077 | |
| chr3:169,811,873–169,814,235 | 149.0 kb | Distal (>10kb) Multiome | 581 |
Genomic view of the MECOM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.