MAP2K1

MAP2K1

mitogen-activated protein kinase kinase 1 | MAPKK1, MEK1, MKK1, PRKMK1

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.2 Developmental clusters: GC2

Biological processes 98 terms

ATP binding (GO:0005524)ERBB signaling pathway (GO:0038127)ERBB2-ERBB3 signaling pathway (GO:0038133)ERK1 and ERK2 cascade (GO:0070371)Golgi apparatus (GO:0005794)Golgi inheritance (GO:0048313)MAP kinase kinase activity (GO:0004708)MAP kinase kinase activity (GO:0004708)MAP kinase kinase activity (GO:0004708)MAP kinase scaffold activity (GO:0005078)MAP kinase scaffold activity (GO:0005078)MAPK cascade (GO:0000165)MAPK cascade (GO:0000165)Schwann cell development (GO:0014044)axon (GO:0030424)cell cortex (GO:0005938)cellular senescence (GO:0090398)centrosome (GO:0005813)chemotaxis (GO:0006935)ciliary basal body (GO:0036064)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)dendrite (GO:0030425)dendrite cytoplasm (GO:0032839)early endosome (GO:0005769)early endosome (GO:0005769)endoplasmic reticulum (GO:0005783)focal adhesion (GO:0005925)focal adhesion (GO:0005925)glutamatergic synapse (GO:0098978)insulin-like growth factor receptor signaling pathway (GO:0048009)late endosome (GO:0005770)late endosome (GO:0005770)melanosome transport (GO:0032402)membrane (GO:0016020)microtubule (GO:0005874)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitogen-activated protein kinase kinase kinase binding (GO:0031435)myelination (GO:0042552)negative regulation of cell population proliferation (GO:0008285)negative regulation of gene expression (GO:0010629)negative regulation of homotypic cell-cell adhesion (GO:0034111)negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway (GO:1903298)neuromuscular junction development (GO:0007528)neuron differentiation (GO:0030182)neuron differentiation (GO:0030182)neuron projection morphogenesis (GO:0048812)nucleus (GO:0005634)nucleus (GO:0005634)perikaryon (GO:0043204)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)positive regulation of ATP biosynthetic process (GO:2001171)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of MAPK cascade (GO:0043410)positive regulation of autophagy (GO:0010508)positive regulation of cell migration (GO:0030335)positive regulation of gene expression (GO:0010628)positive regulation of gene expression (GO:0010628)positive regulation of muscle contraction (GO:0045933)positive regulation of protein serine/threonine kinase activity (GO:0071902)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)postsynaptic density (GO:0014069)protein binding (GO:0005515)protein binding (GO:0005515)protein kinase activator activity (GO:0030295)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase activator activity (GO:0043539)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine/tyrosine kinase activity (GO:0004712)protein tyrosine kinase activity (GO:0004713)protein-containing complex binding (GO:0044877)regulation of ERK1 and ERK2 cascade (GO:0070372)regulation of Golgi inheritance (GO:0090170)regulation of Golgi inheritance (GO:0090170)regulation of early endosome to late endosome transport (GO:2000641)regulation of early endosome to late endosome transport (GO:2000641)regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696)regulation of stress-activated MAPK cascade (GO:0032872)regulation of stress-activated MAPK cascade (GO:0032872)regulation of vascular associated smooth muscle contraction (GO:0003056)response to axon injury (GO:0048678)response to glucocorticoid (GO:0051384)response to oxidative stress (GO:0006979)scaffold protein binding (GO:0097110)scaffold protein binding (GO:0097110)signal transduction (GO:0007165)small GTPase binding (GO:0031267)triglyceride homeostasis (GO:0070328)vesicle transport along microtubule (GO:0047496)

Expression (TPM)

TFs regulating MAP2K1 0 TFs

Transcription factors with Perturb-seq knockdown data for MAP2K1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP2K1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAP2K1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP2K1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr15:66,252,061–66,253,967	134.3 kb	Distal (>10kb) Multiome	412
	chr15:66,293,215–66,294,349	93.2 kb	Distal (>10kb) Multiome	772
	chr15:66,356,371–66,357,196	30.1 kb	Distal (>10kb) Multiome	889
	chr15:66,386,387–66,387,653	47 bp	At TSS Multiome	899
	chr15:66,472,216–66,473,164	85.7 kb	Distal (>10kb) Multiome HiCAR	208
	chr15:66,497,104–66,498,247	110.9 kb	Distal (>10kb) Multiome HiCAR	1044
	chr15:66,504,543–66,505,655	118.3 kb	Distal (>10kb) Multiome	940
	chr15:66,567,056–66,567,492	180.4 kb	Distal (>10kb) Multiome	294
	chr15:66,592,463–66,593,143	205.9 kb	Distal (>10kb) Multiome	154
	chr15:66,621,672–66,622,446	235.4 kb	Distal (>10kb) Multiome	271
	chr15:66,630,856–66,631,340	244.3 kb	Distal (>10kb) Multiome	284
	chr15:66,670,796–66,671,740	284.4 kb	Distal (>10kb) Multiome	241
	chr15:66,673,331–66,673,903	286.9 kb	Distal (>10kb) Multiome	192
	chr15:66,679,362–66,680,264	293.0 kb	Distal (>10kb) Multiome	541

Genome Browser

Genomic view of the MAP2K1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.