This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for WNK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WNK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WNK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:54,182,249–54,183,769 | 174.6 kb | Distal (>10kb) Multiome | 570 | |
| chrX:54,357,469–54,359,170 | 68 bp | At TSS Multiome | 438 | |
| chrX:54,388,044–54,388,641 | 30.4 kb | Distal (>10kb) Multiome | 49 | |
| chrX:54,439,963–54,440,865 | 82.4 kb | Distal (>10kb) Multiome | 587 | |
| chrX:54,495,407–54,496,558 | 138.1 kb | Distal (>10kb) Multiome | 248 | |
| chrX:54,529,579–54,530,565 | 172.1 kb | Distal (>10kb) Multiome | 641 | |
| chrX:54,639,123–54,640,128 | 281.7 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the WNK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.