This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for TNIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:2,462,245–2,463,183 | 293.6 kb | Distal (>10kb) Multiome | 643 | |
| chr4:2,468,399–2,469,652 | 287.3 kb | Distal (>10kb) Multiome | 858 | |
| chr4:2,535,307–2,537,785 | 219.9 kb | Distal (>10kb) Multiome | 860 | |
| chr4:2,755,816–2,757,021 | 1 bp | At TSS Multiome | 760 | |
| chr4:2,763,947–2,764,427 | 7.9 kb | Proximal (<10kb) Multiome | 311 | |
| chr4:2,792,387–2,793,280 | 36.6 kb | Distal (>10kb) Multiome | 561 | |
| chr4:2,800,892–2,801,392 | 44.8 kb | Distal (>10kb) Multiome HiCAR | 538 | |
| chr4:2,817,772–2,818,865 | 61.9 kb | Distal (>10kb) Multiome | 350 | |
| chr4:2,843,009–2,844,539 | 87.5 kb | Distal (>10kb) Multiome | 762 | |
| chr4:2,867,740–2,868,353 | 111.7 kb | Distal (>10kb) Multiome | 232 | |
| chr4:2,886,596–2,887,030 | 130.5 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr4:2,922,643–2,923,182 | 166.5 kb | Distal (>10kb) Multiome HiCAR | 115 | |
| chr4:2,934,626–2,935,335 | 178.5 kb | Distal (>10kb) Multiome HiCAR | 661 | |
| chr4:2,962,729–2,964,377 | 207.1 kb | Distal (>10kb) Multiome | 1035 |
Genomic view of the TNIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.