This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for SATB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SATB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SATB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:18,201,034–18,202,125 | 224.5 kb | Distal (>10kb) Multiome | 185 | |
| chr3:18,233,890–18,235,270 | 191.4 kb | Distal (>10kb) Multiome | 193 | |
| chr3:18,294,917–18,295,844 | 130.7 kb | Distal (>10kb) Multiome | 290 | |
| chr3:18,423,408–18,423,625 | 2.4 kb | Proximal (<10kb) | 294 | |
| chr3:18,424,179–18,426,346 | 457 bp | At TSS Multiome | 630 | |
| chr3:18,428,126–18,428,428 | 2.1 kb | Proximal (<10kb) | 27 | |
| chr3:18,438,441–18,438,793 | 6.1 kb | Proximal (<10kb) | 60 | |
| chr3:18,443,190–18,446,722 | 19.1 kb | Distal (>10kb) Multiome | 604 |
Genomic view of the SATB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.