BTG2
BTG anti-proliferation factor 2 | APRO1, MGC126063, MGC126064, PC3, TIS21

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.29 Developmental clusters: GC6
Biological processes 21 terms
DNA damage response (GO:0006974)DNA repair (GO:0006281)cellular response to phorbol 13-acetate 12-myristate (GO:1904628)cytoplasm (GO:0005737)cytosol (GO:0005829)extracellular exosome (GO:0070062)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of neuron apoptotic process (GO:0043524)negative regulation of translation (GO:0017148)neuron projection development (GO:0031175)nucleus (GO:0005634)positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)protein binding (GO:0005515)response to electrical stimulus (GO:0051602)response to mechanical stimulus (GO:0009612)response to peptide hormone (GO:0043434)transcription corepressor activity (GO:0003714)
Expression (TPM)
BTG2 — as a Regulated Gene

TFs regulating BTG2 0 TFs

Transcription factors with Perturb-seq knockdown data for BTG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BTG2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:203,005,211–203,007,890 299.9 kb Distal (>10kb) Multiome 874
chr1:203,026,091–203,027,571 279.0 kb Distal (>10kb) Multiome 771
chr1:203,117,633–203,118,111 187.6 kb Distal (>10kb) Multiome 344
chr1:203,127,495–203,128,610 177.2 kb Distal (>10kb) Multiome 317
chr1:203,267,310–203,267,938 37.9 kb Distal (>10kb) Multiome 432
chr1:203,273,131–203,273,728 32.2 kb Distal (>10kb) Multiome 579
chr1:203,290,403–203,291,005 14.9 kb Distal (>10kb) Multiome 474
chr1:203,304,867–203,306,858 97 bp At TSS Multiome 964
chr1:203,306,959–203,308,132 2.3 kb Proximal (<10kb) Multiome 305
chr1:203,320,713–203,321,472 15.5 kb Distal (>10kb) Multiome 331
chr1:203,326,875–203,328,263 22.1 kb Distal (>10kb) Multiome 723
chr1:203,342,300–203,342,959 37.1 kb Distal (>10kb) Multiome 242
chr1:203,369,826–203,371,538 64.8 kb Distal (>10kb) Multiome 235
chr1:203,487,217–203,488,252 182.2 kb Distal (>10kb) Multiome 632
chr1:203,585,330–203,586,179 280.2 kb Distal (>10kb) Multiome 85
chr1:203,592,048–203,592,904 287.0 kb Distal (>10kb) Multiome 170

Genome Browser

Genomic view of the BTG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:202,995,211 – 203,602,904
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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