Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for TSPO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:42,856,601–42,857,716 | 294.3 kb | Distal (>10kb) Multiome | 938 | |
| chr22:42,964,987–42,965,486 | 186.4 kb | Distal (>10kb) Multiome | 332 | |
| chr22:43,014,433–43,015,934 | 136.3 kb | Distal (>10kb) Multiome | 845 | |
| chr22:43,089,058–43,089,753 | 62.2 kb | Distal (>10kb) Multiome | 726 | |
| chr22:43,110,485–43,111,495 | 40.8 kb | Distal (>10kb) Multiome | 485 | |
| chr22:43,142,895–43,143,571 | 8.2 kb | Proximal (<10kb) Multiome | 810 | |
| chr22:43,151,300–43,151,927 | 16 bp | At TSS Multiome | 340 | |
| chr22:43,187,421–43,188,123 | 36.0 kb | Distal (>10kb) Multiome | 819 | |
| chr22:43,216,557–43,217,579 | 65.4 kb | Distal (>10kb) Multiome | 90 | |
| chr22:43,226,308–43,226,848 | 75.0 kb | Distal (>10kb) Multiome | 56 | |
| chr22:43,231,079–43,231,533 | 79.8 kb | Distal (>10kb) Multiome | 240 | |
| chr22:43,343,283–43,343,875 | 191.9 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the TSPO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.