This 15-gene module includes MSH2, ATXN1, SGMS1, DAB1, and SPOCK1, with enrichment in DNA damage response and chromatin remodeling pathways. Knockdown of SMARCC1, DNMT1, SOX11, and ARID1A activates this module. Knockdown of DNAJC19 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.