ARRB1
arrestin beta 1 | ARR1

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Member of: DE-4 DE-4.16 Developmental clusters: GC1
Biological processes 82 terms
G protein-coupled receptor binding (GO:0001664)G protein-coupled receptor binding (GO:0001664)G protein-coupled receptor internalization (GO:0002031)G protein-coupled receptor internalization (GO:0002031)G protein-coupled receptor internalization (GO:0002031)GTPase activator activity (GO:0005096)Golgi membrane (GO:0000139)angiotensin receptor binding (GO:0031701)angiotensin receptor binding (GO:0031701)arrestin family protein binding (GO:1990763)cell surface receptor signaling pathway (GO:0007166)chromatin (GO:0000785)cilium (GO:0005929)clathrin-coated pit (GO:0005905)cysteine-type endopeptidase inhibitor activity (GO:0004869)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle membrane (GO:0030659)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)desensitization of G protein-coupled receptor signaling pathway (GO:0002029)endocytic vesicle membrane (GO:0030666)enzyme binding (GO:0019899)enzyme inhibitor activity (GO:0004857)histone acetyltransferase activity (GO:0004402)insulin-like growth factor receptor binding (GO:0005159)intracellular glucose homeostasis (GO:0001678)intraciliary retrograde transport (GO:0035721)lysosomal membrane (GO:0005765)mitogen-activated protein kinase kinase binding (GO:0031434)molecular adaptor activity (GO:0060090)molecular adaptor activity (GO:0060090)molecular adaptor activity (GO:0060090)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of Notch signaling pathway (GO:0045746)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of interleukin-6 production (GO:0032715)negative regulation of interleukin-8 production (GO:0032717)negative regulation of protein localization to ciliary membrane (GO:1903568)negative regulation of protein ubiquitination (GO:0031397)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of Rho protein signal transduction (GO:0035025)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of intracellular signal transduction (GO:1902533)positive regulation of protein phosphorylation (GO:0001934)positive regulation of receptor internalization (GO:0002092)positive regulation of receptor internalization (GO:0002092)positive regulation of smoothened signaling pathway (GO:0045880)positive regulation of smoothened signaling pathway (GO:0045880)positive regulation of transcription by RNA polymerase II (GO:0045944)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein localization to non-motile cilium (GO:0097499)protein localization to non-motile cilium (GO:0097499)protein ubiquitination (GO:0016567)protein-macromolecule adaptor activity (GO:0030674)pseudopodium (GO:0031143)regulation of apoptotic process (GO:0042981)regulation of transcription by RNA polymerase II (GO:0006357)sensory perception (GO:0007600)signal transduction (GO:0007165)stress fiber assembly (GO:0043149)transcription coactivator activity (GO:0003713)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)
Expression (TPM)
ARRB1 — as a Regulated Gene

TFs regulating ARRB1 0 TFs

Transcription factors with Perturb-seq knockdown data for ARRB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARRB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ARRB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARRB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:75,240,428–75,242,358 110.0 kb Distal (>10kb) Multiome 618
chr11:75,331,054–75,332,820 19.6 kb Distal (>10kb) Multiome 273
chr11:75,343,281–75,343,976 8.0 kb Proximal (<10kb) Multiome 375
chr11:75,349,505–75,349,812 1.9 kb Proximal (<10kb) 205
chr11:75,350,692–75,351,052 652 bp At TSS 369
chr11:75,351,219–75,352,738 558 bp At TSS Multiome 868
chr11:75,388,579–75,389,156 37.1 kb Distal (>10kb) Multiome 323
chr11:75,399,325–75,400,051 47.8 kb Distal (>10kb) Multiome 982
chr11:75,425,349–75,425,850 74.0 kb Distal (>10kb) Multiome 134
chr11:75,427,839–75,428,742 76.7 kb Distal (>10kb) Multiome 209
chr11:75,429,695–75,430,823 78.5 kb Distal (>10kb) Multiome 340
chr11:75,524,766–75,526,517 174.3 kb Distal (>10kb) Multiome 663
chr11:75,547,627–75,548,081 196.1 kb Distal (>10kb) Multiome 241
chr11:75,554,271–75,554,862 202.9 kb Distal (>10kb) Multiome 441
chr11:75,559,107–75,559,968 207.8 kb Distal (>10kb) Multiome 262
chr11:75,561,674–75,564,448 210.5 kb Distal (>10kb) Multiome 813
chr11:75,582,925–75,584,268 232.2 kb Distal (>10kb) Multiome 489

Genome Browser

Genomic view of the ARRB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:75,230,428 – 75,594,268
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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