This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for PALLD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PALLD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PALLD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:168,479,889–168,480,830 | 351.7 kb | Distal (>10kb) Multiome | 643 | |
| chr4:168,536,337–168,537,001 | 295.3 kb | Distal (>10kb) Multiome | 148 | |
| chr4:168,631,143–168,632,215 | 200.4 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr4:168,632,316–168,632,726 | 700 bp | At TSS | 125 | |
| chr4:168,776,999–168,778,122 | 54.5 kb | Distal (>10kb) Multiome | 197 | |
| chr4:168,784,585–168,785,381 | 47.0 kb | Distal (>10kb) Multiome | 118 | |
| chr4:168,791,031–168,792,300 | 40.5 kb | Distal (>10kb) Multiome | 100 | |
| chr4:168,831,310–168,831,437 | 605 bp | At TSS | 41 | |
| chr4:168,831,537–168,833,615 | 62 bp | At TSS Multiome HiCAR | 717 | |
| chr4:168,840,956–168,841,663 | 9.2 kb | Proximal (<10kb) Multiome | 151 | |
| chr4:168,877,483–168,878,555 | 45.9 kb | Distal (>10kb) Multiome | 268 | |
| chr4:169,009,429–169,010,942 | 178.3 kb | Distal (>10kb) Multiome | 829 | |
| chr4:169,069,656–169,070,749 | 238.2 kb | Distal (>10kb) Multiome | 482 | |
| chr4:169,100,408–169,101,097 | 268.7 kb | Distal (>10kb) Multiome | 151 |
Genomic view of the PALLD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.