BBC3
BCL2 binding component 3 | JFY1, PUMA

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Member of: DE-4 DE-4.8 Developmental clusters: GC7
Biological processes 42 terms
ATPase binding (GO:0051117)DNA damage response (GO:0006974)DNA damage response (GO:0006974)apoptotic process (GO:0006915)apoptotic signaling pathway (GO:0097190)cellular response to hypoxia (GO:0071456)cytosol (GO:0005829)determination of adult lifespan (GO:0008340)determination of adult lifespan (GO:0008340)execution phase of apoptosis (GO:0097194)execution phase of apoptosis (GO:0097194)intrinsic apoptotic signaling pathway (GO:0097193)intrinsic apoptotic signaling pathway (GO:0097193)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)lysosome (GO:0005764)mitochondrial outer membrane (GO:0005741)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)positive regulation of IRE1-mediated unfolded protein response (GO:1903896)positive regulation of apoptotic process (GO:0043065)positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902237)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)positive regulation of neuron apoptotic process (GO:0043525)positive regulation of neuron apoptotic process (GO:0043525)positive regulation of protein-containing complex assembly (GO:0031334)positive regulation of release of cytochrome c from mitochondria (GO:0090200)positive regulation of release of cytochrome c from mitochondria (GO:0090200)positive regulation of release of cytochrome c from mitochondria (GO:0090200)positive regulation of thymocyte apoptotic process (GO:0070245)positive regulation of thymocyte apoptotic process (GO:0070245)protein binding (GO:0005515)release of cytochrome c from mitochondria (GO:0001836)release of cytochrome c from mitochondria (GO:0001836)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)
Expression (TPM)
BBC3 — as a Regulated Gene

TFs regulating BBC3 0 TFs

Transcription factors with Perturb-seq knockdown data for BBC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BBC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BBC3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BBC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:47,019,502–47,020,076 213.0 kb Distal (>10kb) Multiome 188
chr19:47,035,599–47,036,293 196.8 kb Distal (>10kb) Multiome 627
chr19:47,047,837–47,048,980 184.9 kb Distal (>10kb) Multiome 760
chr19:47,058,561–47,059,308 173.8 kb Distal (>10kb) Multiome 357
chr19:47,111,821–47,113,936 120.6 kb Distal (>10kb) Multiome 1117
chr19:47,130,439–47,131,651 101.9 kb Distal (>10kb) Multiome 908
chr19:47,157,325–47,158,494 75.2 kb Distal (>10kb) Multiome 271
chr19:47,196,586–47,197,452 35.9 kb Distal (>10kb) Multiome 94
chr19:47,225,386–47,231,990 5.0 kb Proximal (<10kb) Multiome 1389
chr19:47,239,497–47,240,166 6.7 kb Proximal (<10kb) 164
chr19:47,240,827–47,241,572 8.4 kb Proximal (<10kb) Multiome 616
chr19:47,242,713–47,243,645 10.4 kb Distal (>10kb) Multiome 568
chr19:47,243,835–47,244,896 11.6 kb Distal (>10kb) Multiome 1001
chr19:47,256,041–47,258,057 24.3 kb Distal (>10kb) Multiome 907
chr19:47,272,778–47,275,890 40.6 kb Distal (>10kb) Multiome 931
chr19:47,348,695–47,349,758 116.4 kb Distal (>10kb) Multiome 766
chr19:47,406,825–47,407,408 174.5 kb Distal (>10kb) Multiome 333
chr19:47,427,132–47,428,809 194.5 kb Distal (>10kb) Multiome 506
chr19:47,429,865–47,430,531 197.6 kb Distal (>10kb) Multiome 438
chr19:47,447,043–47,448,262 214.9 kb Distal (>10kb) Multiome 510
chr19:47,471,631–47,472,340 239.3 kb Distal (>10kb) Multiome 500
chr19:47,479,940–47,480,772 247.4 kb Distal (>10kb) Multiome 147
chr19:47,483,636–47,484,543 251.4 kb Distal (>10kb) Multiome 841
chr19:47,514,152–47,515,901 282.5 kb Distal (>10kb) Multiome 895

Genome Browser

Genomic view of the BBC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:47,009,502 – 47,525,901
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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