This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for MYH9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYH9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYH9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:36,123,849–36,124,433 | 263.8 kb | Distal (>10kb) Multiome | 670 | |
| chr22:36,161,582–36,162,255 | 226.0 kb | Distal (>10kb) Multiome | 66 | |
| chr22:36,172,028–36,172,599 | 215.7 kb | Distal (>10kb) Multiome | 53 | |
| chr22:36,386,961–36,388,711 | 220 bp | At TSS Multiome | 830 | |
| chr22:36,409,675–36,410,687 | 22.2 kb | Distal (>10kb) Multiome | 707 | |
| chr22:36,454,782–36,455,724 | 67.3 kb | Distal (>10kb) Multiome | 598 | |
| chr22:36,459,142–36,459,906 | 71.5 kb | Distal (>10kb) Multiome | 269 | |
| chr22:36,481,299–36,482,295 | 94.0 kb | Distal (>10kb) Multiome | 842 | |
| chr22:36,506,747–36,507,706 | 119.1 kb | Distal (>10kb) Multiome | 964 | |
| chr22:36,528,683–36,529,724 | 141.4 kb | Distal (>10kb) Multiome | 1012 |
Genomic view of the MYH9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.