Enables G-rich strand telomeric DNA binding activity and phosphatase binding activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; protection from non-homologous end joining at telomere; and regulation of primary metabolic process. Located in chromosome, telomeric region; cytoplasm; and nuclear body. Part of shelterin complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TERF2IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TERF2IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TERF2IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:75,432,825–75,434,426 | 214.2 kb | Distal (>10kb) Multiome | 1143 | |
| chr16:75,463,598–75,465,197 | 183.1 kb | Distal (>10kb) Multiome | 999 | |
| chr16:75,494,705–75,495,929 | 152.3 kb | Distal (>10kb) Multiome | 341 | |
| chr16:75,516,521–75,518,019 | 130.4 kb | Distal (>10kb) Multiome | 921 | |
| chr16:75,555,188–75,556,662 | 92.5 kb | Distal (>10kb) Multiome | 900 | |
| chr16:75,565,779–75,567,123 | 81.5 kb | Distal (>10kb) Multiome | 834 | |
| chr16:75,593,861–75,594,383 | 53.6 kb | Distal (>10kb) Multiome | 336 | |
| chr16:75,622,804–75,623,690 | 24.5 kb | Distal (>10kb) Multiome | 852 | |
| chr16:75,647,337–75,649,003 | 1.1 kb | Proximal (<10kb) Multiome | 1002 | |
| chr16:75,649,708–75,650,004 | 1.9 kb | Proximal (<10kb) | 103 | |
| chr16:77,190,160–77,191,630 | 1543.0 kb | Distal (>10kb) Multiome HiCAR | 915 | |
| chr16:77,211,464–77,213,653 | 1564.6 kb | Distal (>10kb) Multiome HiCAR | 644 |
Genomic view of the TERF2IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.