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DE-4.1

Submodule 67 genes

Actin cytoskeleton and muscle contractile organization

This 67-gene module includes CXCR4, IDH1, HSPB1, CDC42, and PKM, with strong enrichment for actin cytoskeleton components, actin filament organization, and contractile muscle fiber structures. The module also shows enrichment for platelet activation and aggregation, suggesting a role in cellular contractility and morphodynamics. No TF knockdown data are available for this module.

Key terms: anatomical structure development anatomical structure morphogenesis multicellular organismal process developmental process Notable genes: CXCR4 IDH1 HSPB1 CDC42 PKM SPARC FLNA SLC7A5

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (67)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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