Enables phospholipid scramblase activity. Involved in antiviral innate immune response and plasma membrane phospholipid scrambling. Located in several cellular components, including centrosome; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SERINC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERINC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERINC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:79,990,706–79,991,420 | 264.9 kb | Distal (>10kb) Multiome | 773 | |
| chr5:80,034,875–80,035,788 | 220.7 kb | Distal (>10kb) Multiome | 189 | |
| chr5:80,093,737–80,094,335 | 161.9 kb | Distal (>10kb) Multiome HiCAR | 220 | |
| chr5:80,111,066–80,112,197 | 144.5 kb | Distal (>10kb) Multiome HiCAR | 104 | |
| chr5:80,141,245–80,141,718 | 114.5 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr5:80,180,501–80,181,544 | 75.0 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr5:80,183,069–80,185,467 | 72.6 kb | Distal (>10kb) Multiome HiCAR | 646 | |
| chr5:80,185,568–80,186,143 | 70.3 kb | Distal (>10kb) Multiome HiCAR | 70 | |
| chr5:80,204,750–80,205,627 | 51.0 kb | Distal (>10kb) Multiome | 594 | |
| chr5:80,247,275–80,247,779 | 8.3 kb | Proximal (<10kb) | 502 | |
| chr5:80,255,259–80,256,736 | 46 bp | At TSS Multiome | 873 | |
| chr5:80,257,220–80,257,979 | 1.7 kb | Proximal (<10kb) Multiome | 496 | |
| chr5:80,407,421–80,408,673 | 152.0 kb | Distal (>10kb) Multiome | 954 | |
| chr5:80,487,503–80,488,829 | 232.1 kb | Distal (>10kb) Multiome | 871 | |
| chr5:80,554,442–80,555,055 | 298.8 kb | Distal (>10kb) Multiome | 148 |
Genomic view of the SERINC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.