This 57-gene module includes FOXO3, LMNA, WWTR1, MAP2K1, and CTNND1, with enrichment in cytoskeletal organization, stress response, and signaling pathways. Knockdown of FOXH1, SOX17, and TAF10 activates this module. Knockdown of ARID1A, ZNF431, and TCEB3 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.