This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CXCR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CXCR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CXCR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:135,875,648–135,876,919 | 241.7 kb | Distal (>10kb) Multiome | 849 | |
| chr2:135,984,898–135,986,233 | 132.5 kb | Distal (>10kb) Multiome | 1057 | |
| chr2:136,025,017–136,026,218 | 92.5 kb | Distal (>10kb) Multiome | 322 | |
| chr2:136,111,604–136,112,087 | 4.2 kb | Proximal (<10kb) | 25 | |
| chr2:136,112,260–136,113,070 | 3.2 kb | Proximal (<10kb) | 99 | |
| chr2:136,115,192–136,115,948 | 294 bp | At TSS | 75 | |
| chr2:136,116,129–136,119,923 | 1.3 kb | Proximal (<10kb) Multiome | 623 | |
| chr2:136,125,768–136,126,914 | 8.1 kb | Proximal (<10kb) Multiome | 196 | |
| chr2:136,127,705–136,128,180 | 9.6 kb | Proximal (<10kb) | 27 | |
| chr2:136,178,675–136,180,367 | 61.5 kb | Distal (>10kb) Multiome | 287 | |
| chr2:136,319,261–136,320,292 | 201.6 kb | Distal (>10kb) Multiome | 229 |
Genomic view of the CXCR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.