The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for FRZB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRZB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRZB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:182,715,568–182,716,979 | 150.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr2:182,860,765–182,861,463 | 5.2 kb | Proximal (<10kb) | 60 | |
| chr2:182,865,796–182,867,716 | 480 bp | At TSS Multiome | 424 | |
| chr2:182,868,113–182,868,264 | 1.5 kb | Proximal (<10kb) | 83 | |
| chr2:182,870,321–182,870,504 | 3.7 kb | Proximal (<10kb) | 65 | |
| chr2:182,929,762–182,930,671 | 63.6 kb | Distal (>10kb) Multiome | 149 | |
| chr2:183,037,288–183,039,108 | 171.9 kb | Distal (>10kb) Multiome | 915 | |
| chr2:183,078,264–183,079,391 | 212.1 kb | Distal (>10kb) Multiome | 744 | |
| chr2:183,123,970–183,125,139 | 257.8 kb | Distal (>10kb) Multiome | 982 |
Genomic view of the FRZB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.