This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EIF4EBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4EBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4EBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:37,735,982–37,737,291 | 294.0 kb | Distal (>10kb) Multiome | 958 | |
| chr8:37,762,144–37,763,270 | 268.0 kb | Distal (>10kb) Multiome | 889 | |
| chr8:37,796,327–37,797,580 | 233.7 kb | Distal (>10kb) Multiome | 485 | |
| chr8:37,801,462–37,802,090 | 228.7 kb | Distal (>10kb) Multiome | 164 | |
| chr8:37,821,399–37,822,221 | 208.7 kb | Distal (>10kb) Multiome | 284 | |
| chr8:37,826,056–37,826,968 | 203.9 kb | Distal (>10kb) Multiome | 259 | |
| chr8:37,849,554–37,850,089 | 180.6 kb | Distal (>10kb) Multiome | 929 | |
| chr8:37,898,759–37,900,024 | 131.0 kb | Distal (>10kb) Multiome | 956 | |
| chr8:37,915,980–37,916,519 | 114.2 kb | Distal (>10kb) Multiome | 465 | |
| chr8:37,965,216–37,966,371 | 64.9 kb | Distal (>10kb) Multiome | 177 | |
| chr8:38,015,136–38,015,926 | 15.0 kb | Distal (>10kb) Multiome | 59 | |
| chr8:38,029,913–38,031,249 | 62 bp | At TSS Multiome | 948 | |
| chr8:38,031,341–38,031,779 | 808 bp | At TSS | 591 | |
| chr8:38,066,984–38,067,582 | 36.7 kb | Distal (>10kb) Multiome | 414 | |
| chr8:38,070,928–38,072,232 | 41.2 kb | Distal (>10kb) Multiome | 282 | |
| chr8:38,104,797–38,106,255 | 75.2 kb | Distal (>10kb) Multiome | 954 | |
| chr8:38,108,727–38,109,662 | 78.6 kb | Distal (>10kb) Multiome | 83 | |
| chr8:38,175,948–38,177,501 | 146.2 kb | Distal (>10kb) Multiome | 870 | |
| chr8:38,230,935–38,232,445 | 201.0 kb | Distal (>10kb) Multiome | 904 | |
| chr8:38,268,159–38,269,673 | 238.7 kb | Distal (>10kb) Multiome | 795 |
Genomic view of the EIF4EBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.