This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for SLC1A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC1A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC1A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:4,297,147–4,298,870 | 192.6 kb | Distal (>10kb) Multiome | 611 | |
| chr9:4,298,980–4,300,334 | 190.5 kb | Distal (>10kb) Multiome | 451 | |
| chr9:4,489,445–4,492,426 | 1.3 kb | Proximal (<10kb) Multiome | 545 | |
| chr9:4,507,563–4,508,683 | 17.8 kb | Distal (>10kb) Multiome | 213 | |
| chr9:4,514,255–4,515,200 | 24.4 kb | Distal (>10kb) Multiome | 105 | |
| chr9:4,661,662–4,663,256 | 171.9 kb | Distal (>10kb) Multiome | 925 | |
| chr9:4,678,800–4,680,345 | 189.1 kb | Distal (>10kb) Multiome | 960 | |
| chr9:4,740,523–4,742,116 | 250.8 kb | Distal (>10kb) Multiome | 942 | |
| chr9:4,762,590–4,763,629 | 272.9 kb | Distal (>10kb) Multiome | 504 | |
| chr9:5,831,978–5,833,476 | 1342.5 kb | Distal (>10kb) Multiome HiCAR | 896 |
Genomic view of the SLC1A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.