This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ERBB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERBB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERBB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:211,331,626–211,332,499 | 1097.4 kb | Distal (>10kb) Multiome HiCAR | 183 | |
| chr2:211,591,405–211,592,804 | 837.1 kb | Distal (>10kb) Multiome HiCAR | 109 | |
| chr2:211,742,926–211,744,057 | 685.7 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr2:211,766,641–211,767,274 | 662.4 kb | Distal (>10kb) Multiome HiCAR | 187 | |
| chr2:212,426,722–212,427,290 | 2.0 kb | Proximal (<10kb) | 23 | |
| chr2:212,428,776–212,429,503 | at TSS | At TSS | 176 | |
| chr2:212,536,027–212,539,802 | 110.0 kb | Distal (>10kb) Multiome | 723 | |
| chr2:212,548,566–212,548,816 | 9.7 kb | Proximal (<10kb) | 41 |
Genomic view of the ERBB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.