The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for DAB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:58,249,625–58,250,892 | 296.3 kb | Distal (>10kb) Multiome | 329 | |
| chr1:58,432,643–58,433,226 | 113.8 kb | Distal (>10kb) Multiome | 176 | |
| chr1:58,447,893–58,448,830 | 98.5 kb | Distal (>10kb) Multiome | 88 | |
| chr1:58,545,902–58,547,165 | 2 bp | At TSS Multiome | 808 | |
| chr1:58,576,513–58,577,828 | 30.5 kb | Distal (>10kb) Multiome | 406 | |
| chr1:58,699,577–58,700,464 | 153.4 kb | Distal (>10kb) Multiome | 702 | |
| chr1:58,704,094–58,705,219 | 158.1 kb | Distal (>10kb) Multiome | 154 | |
| chr1:58,782,095–58,785,778 | 237.4 kb | Distal (>10kb) Multiome | 1186 | |
| chr1:58,814,035–58,816,778 | 269.7 kb | Distal (>10kb) Multiome | 966 |
Genomic view of the DAB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.