The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for C1GALT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1GALT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1GALT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,901,511–6,903,145 | 280.2 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,995,280–6,995,919 | 186.9 kb | Distal (>10kb) Multiome | 100 | |
| chr7:7,099,297–7,099,939 | 82.9 kb | Distal (>10kb) Multiome | 535 | |
| chr7:7,100,140–7,101,112 | 81.9 kb | Distal (>10kb) Multiome | 318 | |
| chr7:7,181,606–7,183,506 | 19 bp | At TSS Multiome | 995 | |
| chr7:7,187,544–7,188,409 | 5.0 kb | Proximal (<10kb) | 42 | |
| chr7:7,190,228–7,190,434 | 7.7 kb | Proximal (<10kb) | 91 | |
| chr7:7,201,233–7,202,308 | 19.2 kb | Distal (>10kb) Multiome | 224 | |
| chr7:7,209,537–7,211,170 | 28.2 kb | Distal (>10kb) Multiome | 223 | |
| chr7:7,352,864–7,353,400 | 170.5 kb | Distal (>10kb) Multiome | 139 | |
| chr7:7,415,971–7,416,912 | 233.7 kb | Distal (>10kb) Multiome HiCAR | 282 |
Genomic view of the C1GALT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.