This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for PIK3CB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3CB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3CB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,608,484–138,609,385 | 225.8 kb | Distal (>10kb) Multiome | 803 | |
| chr3:138,834,175–138,835,445 | 71 bp | At TSS Multiome | 868 | |
| chr3:138,861,682–138,863,746 | 28.0 kb | Distal (>10kb) Multiome | 879 | |
| chr3:138,879,509–138,880,571 | 45.1 kb | Distal (>10kb) Multiome | 216 | |
| chr3:138,914,877–138,916,650 | 81.1 kb | Distal (>10kb) Multiome | 922 | |
| chr3:138,935,795–138,937,399 | 101.4 kb | Distal (>10kb) Multiome | 594 | |
| chr3:138,937,821–138,938,914 | 103.6 kb | Distal (>10kb) Multiome | 119 | |
| chr3:138,944,879–138,947,892 | 112.4 kb | Distal (>10kb) Multiome | 500 | |
| chr3:138,949,729–138,950,605 | 115.4 kb | Distal (>10kb) Multiome | 149 |
Genomic view of the PIK3CB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.