This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for FHOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FHOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FHOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,000,412–67,001,423 | 246.4 kb | Distal (>10kb) Multiome | 270 | |
| chr16:67,013,778–67,014,584 | 233.4 kb | Distal (>10kb) Multiome | 594 | |
| chr16:67,017,916–67,018,379 | 229.4 kb | Distal (>10kb) Multiome | 530 | |
| chr16:67,028,567–67,029,938 | 218.4 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:67,109,102–67,110,434 | 137.7 kb | Distal (>10kb) Multiome | 895 | |
| chr16:67,149,282–67,151,406 | 96.8 kb | Distal (>10kb) Multiome | 693 | |
| chr16:67,154,687–67,155,820 | 92.0 kb | Distal (>10kb) Multiome | 593 | |
| chr16:67,160,628–67,161,206 | 86.4 kb | Distal (>10kb) Multiome | 524 | |
| chr16:67,162,969–67,163,815 | 84.1 kb | Distal (>10kb) Multiome | 238 | |
| chr16:67,169,105–67,171,287 | 77.9 kb | Distal (>10kb) Multiome | 813 | |
| chr16:67,173,849–67,174,861 | 73.2 kb | Distal (>10kb) Multiome | 809 | |
| chr16:67,177,863–67,178,664 | 69.2 kb | Distal (>10kb) Multiome | 544 | |
| chr16:67,183,333–67,184,856 | 63.6 kb | Distal (>10kb) Multiome | 886 | |
| chr16:67,185,256–67,185,693 | 61.9 kb | Distal (>10kb) Multiome | 740 | |
| chr16:67,191,949–67,192,449 | 55.3 kb | Distal (>10kb) Multiome | 781 | |
| chr16:67,198,940–67,200,211 | 47.8 kb | Distal (>10kb) Multiome | 325 | |
| chr16:67,226,487–67,227,575 | 20.5 kb | Distal (>10kb) Multiome | 909 | |
| chr16:67,236,439–67,237,267 | 10.7 kb | Distal (>10kb) Multiome | 195 | |
| chr16:67,245,855–67,247,890 | 82 bp | At TSS Multiome | 1077 | |
| chr16:67,248,206–67,249,338 | 1.6 kb | Proximal (<10kb) Multiome | 467 | |
| chr16:67,262,177–67,262,869 | 15.0 kb | Distal (>10kb) Multiome | 24 | |
| chr16:67,278,724–67,279,792 | 31.9 kb | Distal (>10kb) Multiome | 869 | |
| chr16:67,326,413–67,327,343 | 79.4 kb | Distal (>10kb) Multiome | 585 | |
| chr16:67,393,199–67,393,789 | 146.0 kb | Distal (>10kb) Multiome HiCAR | 377 | |
| chr16:67,396,006–67,396,718 | 149.0 kb | Distal (>10kb) Multiome | 375 | |
| chr16:67,399,230–67,399,872 | 152.1 kb | Distal (>10kb) Multiome HiCAR | 211 | |
| chr16:67,415,996–67,416,812 | 168.9 kb | Distal (>10kb) Multiome HiCAR | 687 | |
| chr16:67,428,012–67,428,783 | 180.8 kb | Distal (>10kb) Multiome | 382 | |
| chr16:67,430,407–67,432,610 | 183.6 kb | Distal (>10kb) Multiome | 790 | |
| chr16:67,480,508–67,481,841 | 233.8 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:67,521,086–67,521,812 | 274.0 kb | Distal (>10kb) Multiome | 775 | |
| chr16:67,528,470–67,529,464 | 281.4 kb | Distal (>10kb) Multiome | 641 | |
| chr16:67,537,215–67,538,620 | 290.6 kb | Distal (>10kb) Multiome | 560 |
Genomic view of the FHOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.