DE-5

Supermodule 1008 genes

DNA binding and RNA catalytic activity module

Module DE-5 contains 1,025 genes including MTHFR, NFKB1, NFE2L2, SIRT1, and SOD2, with enrichment for cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, and catalytic activity acting on RNA. Knockdown of ZC3H3 represses this module. No transcription factors were identified whose knockdown activates this module.

Key terms: RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process nucleic acid metabolic process nucleobase-containing compound biosynthetic process Notable genes: MTHFR NFKB1 NFE2L2 SIRT1 SOD2 TARDBP FMR1 VHL Top TFs: ZC3H3 AATF ADNP AEBP2 AFF1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (31)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-5.1	30	EPOR DKK3 NDRG2 DNAAF4 HPN
DE-5.2	29	CRMP1 BANP FIG4 KREMEN1 ARHGAP18
DE-5.3	24	VHL DNMT3A RXRA TERF2 TBX1
DE-5.4	23	BCL2L1 EFNB2 WWC1 ADAMTS1 PNPT1
DE-5.5	23	STAT6 BBS1 SLC35A1 TOM1L1 MSTO1
DE-5.6	21	PPARA TRPA1 LPIN1 BNIP3L ARID3A
DE-5.7	18	SCN8A JAM3 GALNT3 RGS17 GNB5
DE-5.8	18	CHUK MFN2 LONP1 SETD1A SART3
DE-5.9	17	MTRR SOAT1 OTULIN SPSB1 MSL1
DE-5.10	17	MED12 STAT2 PLEC HEXIM1 MADD
DE-5.11	17	HLA-E HADHB MAP9 TCTN1 ALDH6A1
DE-5.12	15	LANCL2 LTO1 SNAPC4 NOL4L RCL1
DE-5.13	14	GOLPH3 TEAD4 MAML1 PRPF4B LUC7L3
DE-5.14	14	IRS2 IRF2 NFYC CCNL1 TENT4B
DE-5.15	14	POLH ESRP1 CNTN1 RNF115 LNPK
DE-5.16	14	FBF1 ADAMTS7 DEAF1 PRMT7 CREBZF
DE-5.17	14	ADGRG6 NCKIPSD TMEM38B ALG9 LRRC1
DE-5.18	14	BIRC2 IFNGR1 INSIG2 TMEM106B HEXA
DE-5.19	13	SEC14L2 RNF170 FBXO16 PHYKPL TTC23
DE-5.20	12	DHX9 SRPK1 EIF3A DDX6 AMD1
DE-5.21	12	HSPA4 MED1 MFN1 NSUN2 PRPF8
DE-5.22	12	SNX27 E2F5 KIF3B ZNF268 UBE2R2
DE-5.23	12	CARD8 SS18 CDR2 ZFAND6 FEZ2
DE-5.24	12	SENP3 LPCAT1 MLLT1 ITPK1 TNPO2
DE-5.25	11	TARDBP AGO2 DDX3X IGF2BP1 CUL1
DE-5.26	11	CPSF6 TPR BCLAF1 SON CCAR1
DE-5.27	11	MTHFR SMARCAL1 RHOT1 RARRES1 FYCO1
DE-5.28	11	ERN1 BCAR1 SETDB2 PDE6D SBNO2
DE-5.29	11	NR1H3 SNAP23 COX15 TTC5 CKMT2
DE-5.30	10	OPA3 TRIM13 FBXO25 SHPK SLC35F2
DE-5.31	10	STX17 TRDMT1 KCTD20 TUBD1 PTGR3

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).