This module contains 14 genes including BIRC2, IFNGR1, INSIG2, TMEM106B, and HEXA, with top enriched terms related to apoptosis, lysosomal processes, and immune signaling. Knockdown of SOX17 activates this module, while knockdown of FOXA2 and GATA4 repress it. These regulatory relationships suggest the module plays a role in controlling cell survival and lysosomal homeostasis during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.