The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SART3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SART3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SART3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:108,316,165–108,316,921 | 244.6 kb | Distal (>10kb) Multiome | 72 | |
| chr12:108,441,995–108,442,516 | 118.9 kb | Distal (>10kb) Multiome | 196 | |
| chr12:108,514,776–108,515,777 | 46.0 kb | Distal (>10kb) Multiome | 685 | |
| chr12:108,560,717–108,561,713 | 60 bp | At TSS Multiome | 703 | |
| chr12:108,561,872–108,563,300 | 1.4 kb | Proximal (<10kb) Multiome | 772 | |
| chr12:108,563,418–108,563,794 | 2.3 kb | Proximal (<10kb) | 423 | |
| chr12:108,691,447–108,691,929 | 130.6 kb | Distal (>10kb) Multiome | 745 | |
| chr12:108,730,199–108,732,667 | 170.7 kb | Distal (>10kb) Multiome | 993 | |
| chr12:108,802,154–108,802,651 | 241.1 kb | Distal (>10kb) Multiome | 135 | |
| chr12:108,856,753–108,858,260 | 296.5 kb | Distal (>10kb) Multiome | 698 | |
| chr12:109,093,224–109,093,868 | 532.4 kb | Distal (>10kb) Multiome HiCAR | 998 | |
| chr12:109,097,190–109,098,740 | 536.9 kb | Distal (>10kb) Multiome HiCAR | 758 |
Genomic view of the SART3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.