This 11-gene module includes MTHFR, SMARCAL1, RHOT1, RARRES1, and FYCO1, with top enriched terms related to one-carbon metabolism, mitochondrial dynamics, and autophagy. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN, FOXA2, and GATA4 repress it.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.