This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for SOD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:159,168,575–159,170,383 | 523.9 kb | Distal (>10kb) Multiome HiCAR | 353 | |
| chr6:159,691,919–159,692,279 | 998 bp | At TSS | 183 | |
| chr6:159,692,373–159,694,256 | 151 bp | At TSS Multiome | 1061 | |
| chr6:159,726,454–159,728,172 | 34.0 kb | Distal (>10kb) Multiome | 1218 | |
| chr6:159,761,181–159,763,111 | 68.9 kb | Distal (>10kb) Multiome | 1026 | |
| chr6:159,788,809–159,791,272 | 96.5 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:159,968,449–159,970,213 | 275.7 kb | Distal (>10kb) Multiome | 961 |
Genomic view of the SOD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.