This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]
Transcription factors with Perturb-seq knockdown data for KREMEN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KREMEN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KREMEN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:28,772,518–28,773,373 | 300.2 kb | Distal (>10kb) Multiome | 796 | |
| chr22:28,800,006–28,801,035 | 272.4 kb | Distal (>10kb) Multiome | 829 | |
| chr22:28,882,670–28,884,893 | 189.7 kb | Distal (>10kb) Multiome | 802 | |
| chr22:29,004,535–29,005,249 | 68.1 kb | Distal (>10kb) Multiome | 417 | |
| chr22:29,029,712–29,031,115 | 42.2 kb | Distal (>10kb) Multiome | 773 | |
| chr22:29,071,484–29,071,874 | 1.5 kb | Proximal (<10kb) Multiome | 332 | |
| chr22:29,072,494–29,074,480 | 103 bp | At TSS Multiome | 537 | |
| chr22:29,205,602–29,206,473 | 133.0 kb | Distal (>10kb) Multiome | 378 | |
| chr22:29,267,574–29,268,917 | 195.1 kb | Distal (>10kb) Multiome | 969 | |
| chr22:29,304,664–29,307,808 | 233.9 kb | Distal (>10kb) Multiome | 839 | |
| chr22:29,313,065–29,313,784 | 240.3 kb | Distal (>10kb) Multiome | 274 | |
| chr22:29,315,074–29,316,064 | 242.6 kb | Distal (>10kb) Multiome | 242 |
Genomic view of the KREMEN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.