SBNO2
strawberry notch homolog 2 | FLJ00173, Sno, Stno, KIAA0963

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to interleukin-6; macrophage activation involved in immune response; and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.28 Developmental clusters: GC2
Biological processes 24 terms
cellular response to interleukin-11 (GO:0071348)cellular response to interleukin-11 (GO:0071348)cellular response to interleukin-6 (GO:0071354)cellular response to interleukin-6 (GO:0071354)cellular response to interleukin-6 (GO:0071354)cellular response to leukemia inhibitory factor (GO:1990830)cellular response to leukemia inhibitory factor (GO:1990830)cellular response to lipopolysaccharide (GO:0071222)cellular response to lipopolysaccharide (GO:0071222)chromatin DNA binding (GO:0031490)histone binding (GO:0042393)macrophage activation involved in immune response (GO:0002281)macrophage activation involved in immune response (GO:0002281)macrophage activation involved in immune response (GO:0002281)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)nucleus (GO:0005634)osteoclast differentiation (GO:0030316)positive regulation of transcription by RNA polymerase II (GO:0045944)regulation of DNA-templated transcription (GO:0006355)regulation of inflammatory response (GO:0050727)regulation of inflammatory response (GO:0050727)regulation of inflammatory response (GO:0050727)
Expression (TPM)
SBNO2 — as a Regulated Gene

TFs regulating SBNO2 0 TFs

Transcription factors with Perturb-seq knockdown data for SBNO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SBNO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SBNO2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SBNO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:892,703–893,746 281.1 kb Distal (>10kb) Multiome 715
chr19:917,038–918,169 256.4 kb Distal (>10kb) Multiome 711
chr19:924,743–926,242 248.6 kb Distal (>10kb) Multiome 796
chr19:927,058–927,629 246.9 kb Distal (>10kb) Multiome 362
chr19:982,565–983,215 191.4 kb Distal (>10kb) Multiome 590
chr19:984,046–985,154 189.8 kb Distal (>10kb) Multiome 829
chr19:1,000,142–1,000,881 173.9 kb Distal (>10kb) Multiome 399
chr19:1,020,611–1,022,069 152.9 kb Distal (>10kb) Multiome 1017
chr19:1,026,155–1,026,856 147.8 kb Distal (>10kb) Multiome 598
chr19:1,027,770–1,028,926 145.7 kb Distal (>10kb) Multiome 584
chr19:1,039,648–1,040,400 134.3 kb Distal (>10kb) Multiome 684
chr19:1,040,481–1,041,402 133.1 kb Distal (>10kb) Multiome 556
chr19:1,044,758–1,045,598 128.9 kb Distal (>10kb) Multiome 402
chr19:1,061,840–1,062,923 111.7 kb Distal (>10kb) Multiome 204
chr19:1,063,045–1,065,722 109.4 kb Distal (>10kb) Multiome 681
chr19:1,066,682–1,067,587 107.0 kb Distal (>10kb) Multiome 489
chr19:1,071,107–1,071,721 103.1 kb Distal (>10kb) Multiome 178
chr19:1,081,317–1,083,172 91.8 kb Distal (>10kb) Multiome 484
chr19:1,094,985–1,095,654 78.8 kb Distal (>10kb) Multiome 671
chr19:1,103,487–1,105,654 70.3 kb Distal (>10kb) Multiome 849
chr19:1,112,029–1,112,884 62.0 kb Distal (>10kb) Multiome 294
chr19:1,113,014–1,114,139 60.7 kb Distal (>10kb) Multiome 690
chr19:1,122,934–1,123,720 51.0 kb Distal (>10kb) Multiome 231
chr19:1,173,441–1,174,438 42 bp At TSS Multiome 682
chr19:1,194,370–1,194,985 20.4 kb Distal (>10kb) Multiome 531
chr19:1,205,175–1,206,374 31.3 kb Distal (>10kb) Multiome 746
chr19:1,237,080–1,238,434 63.8 kb Distal (>10kb) Multiome 430
chr19:1,239,513–1,242,539 67.5 kb Distal (>10kb) Multiome 889
chr19:1,244,253–1,244,857 70.3 kb Distal (>10kb) Multiome 590
chr19:1,247,981–1,252,501 76.8 kb Distal (>10kb) Multiome 1136
chr19:1,259,185–1,262,955 85.1 kb Distal (>10kb) Multiome 1070
chr19:1,265,280–1,270,235 95.0 kb Distal (>10kb) Multiome 1171
chr19:1,274,423–1,276,502 101.5 kb Distal (>10kb) Multiome 967
chr19:1,285,317–1,286,108 111.5 kb Distal (>10kb) Multiome 277
chr19:1,354,303–1,355,411 180.6 kb Distal (>10kb) Multiome 688
chr19:1,383,122–1,384,333 209.4 kb Distal (>10kb) Multiome 1228
chr19:1,401,101–1,401,839 227.3 kb Distal (>10kb) Multiome 540
chr19:1,406,589–1,408,783 233.2 kb Distal (>10kb) Multiome 911
chr19:1,415,008–1,415,721 241.2 kb Distal (>10kb) Multiome 597
chr19:1,437,988–1,438,998 264.1 kb Distal (>10kb) Multiome 1076
chr19:1,444,785–1,447,383 271.0 kb Distal (>10kb) Multiome 797
chr19:1,455,191–1,456,421 281.5 kb Distal (>10kb) Multiome 491
chr19:1,468,941–1,469,903 295.0 kb Distal (>10kb) Multiome 242
chr19:1,470,088–1,471,597 296.5 kb Distal (>10kb) Multiome 544

Genome Browser

Genomic view of the SBNO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:882,703 – 1,481,597
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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