RNF115
ring finger protein 115 | BCA2, CL469780, Rabring7, ZNF364

Enables ubiquitin protein ligase activity. Involved in negative regulation of signal transduction; protein ubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.15
Biological processes 27 terms
Golgi apparatus (GO:0005794)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)negative regulation of toll-like receptor signaling pathway (GO:0034122)nucleus (GO:0005634)protein K11-linked ubiquitination (GO:0070979)protein K48-linked ubiquitination (GO:0070936)protein K48-linked ubiquitination (GO:0070936)protein K63-linked ubiquitination (GO:0070534)protein K63-linked ubiquitination (GO:0070534)protein autoubiquitination (GO:0051865)protein binding (GO:0005515)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
RNF115 — as a Regulated Gene

TFs regulating RNF115 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF115. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF115 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RNF115

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF115, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:145,607,803–145,608,364 216.1 kb Distal (>10kb) Multiome 205
chr1:145,707,296–145,708,738 116.0 kb Distal (>10kb) Multiome 511
chr1:145,720,881–145,721,650 102.8 kb Distal (>10kb) Multiome 548
chr1:145,823,605–145,824,539 22 bp At TSS Multiome 899
chr1:145,845,315–145,846,128 21.6 kb Distal (>10kb) Multiome 750
chr1:145,858,348–145,860,193 35.9 kb Distal (>10kb) Multiome 828
chr1:145,885,653–145,886,460 62.0 kb Distal (>10kb) Multiome 327
chr1:145,891,718–145,892,684 68.0 kb Distal (>10kb) Multiome 738
chr1:145,918,087–145,919,947 94.8 kb Distal (>10kb) Multiome 724
chr1:145,926,848–145,927,896 103.4 kb Distal (>10kb) Multiome 890
chr1:145,932,283–145,933,321 108.7 kb Distal (>10kb) Multiome 308
chr1:145,957,545–145,958,280 133.9 kb Distal (>10kb) Multiome 631
chr1:145,960,287–145,961,311 136.6 kb Distal (>10kb) Multiome 498
chr1:145,964,302–145,964,971 140.5 kb Distal (>10kb) Multiome 662
chr1:145,978,977–145,980,010 155.4 kb Distal (>10kb) Multiome 689
chr1:145,996,493–145,997,058 172.6 kb Distal (>10kb) Multiome 911
chr1:146,035,364–146,036,312 211.6 kb Distal (>10kb) Multiome 845
chr1:146,036,931–146,039,723 213.0 kb Distal (>10kb) Multiome 1048
chr1:146,051,092–146,052,696 228.1 kb Distal (>10kb) Multiome 1182

Genome Browser

Genomic view of the RNF115 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:145,597,803 – 146,062,696
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact