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DE-5.25

Submodule 11 genes

mRNA binding and metabolic regulation

This 11-gene module includes TARDBP, AGO2, DDX3X, IGF2BP1, and CUL1, and is enriched for mRNA binding and mRNA metabolic processes, including negative regulation of protein metabolism. No transcription factor knockdown data were available for activation of this module. No transcription factor knockdown data were available for repression of this module.

Key terms: mRNA metabolic process negative regulation of translation mRNA destabilization RNA destabilization Notable genes: TARDBP AGO2 DDX3X IGF2BP1 CUL1 FUBP1 SAFB HNRNPH1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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