The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for STAT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STAT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STAT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,751,814–56,752,566 | 359.1 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr12:57,006,056–57,006,942 | 104.8 kb | Distal (>10kb) Multiome HiCAR | 422 | |
| chr12:57,078,210–57,079,177 | 32.5 kb | Distal (>10kb) Multiome HiCAR | 778 | |
| chr12:57,086,367–57,089,469 | 22.5 kb | Distal (>10kb) Multiome | 1047 | |
| chr12:57,093,695–57,094,140 | 17.2 kb | Distal (>10kb) Multiome | 243 | |
| chr12:57,110,045–57,111,598 | 933 bp | At TSS Multiome HiCAR | 656 | |
| chr12:57,111,611–57,112,633 | 1.0 kb | Proximal (<10kb) Multiome HiCAR | 940 | |
| chr12:57,124,349–57,124,563 | 4.5 kb | Proximal (<10kb) | 210 | |
| chr12:57,127,277–57,129,227 | 16.8 kb | Distal (>10kb) Multiome HiCAR | 725 | |
| chr12:57,214,315–57,214,722 | 103.2 kb | Distal (>10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 105.3 kb | Distal (>10kb) Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 108.1 kb | Distal (>10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 113.7 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 115.7 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 118.4 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 127.8 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 132.4 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 159.8 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 161.5 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 266.3 kb | Distal (>10kb) Multiome | 170 |
Genomic view of the STAT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.