FBF1
Fas binding factor 1 | ALB, FBF-1, FLJ00103, KIAA1863

Involved in apical junction assembly and establishment of epithelial cell polarity. Acts upstream of or within cilium assembly. Located in apical junction complex and cytoskeleton. Part of ciliary transition fiber. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.16
Biological processes 22 terms
anchoring junction (GO:0070161)apical junction assembly (GO:0043297)apical junction complex (GO:0043296)centriole (GO:0005814)centriole (GO:0005814)centriole (GO:0005814)centrosome (GO:0005813)ciliary basal body (GO:0036064)ciliary basal body (GO:0036064)ciliary transition fiber (GO:0097539)ciliary transition fiber (GO:0097539)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cytosol (GO:0005829)establishment of epithelial cell polarity (GO:0090162)establishment of epithelial cell polarity (GO:0090162)keratin filament (GO:0045095)protein binding (GO:0005515)spindle pole (GO:0000922)spindle pole (GO:0000922)
Expression (TPM)
FBF1 — as a Regulated Gene

TFs regulating FBF1 0 TFs

Transcription factors with Perturb-seq knockdown data for FBF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FBF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:75,666,763–75,667,767 273.9 kb Distal (>10kb) Multiome 783
chr17:75,720,933–75,721,693 219.8 kb Distal (>10kb) Multiome 509
chr17:75,753,534–75,754,285 187.3 kb Distal (>10kb) Multiome 699
chr17:75,764,621–75,765,674 176.0 kb Distal (>10kb) Multiome 769
chr17:75,778,786–75,780,191 161.3 kb Distal (>10kb) Multiome 1118
chr17:75,784,060–75,785,640 156.3 kb Distal (>10kb) Multiome 1176
chr17:75,827,420–75,828,293 113.3 kb Distal (>10kb) Multiome 404
chr17:75,830,158–75,830,695 110.8 kb Distal (>10kb) Multiome 190
chr17:75,832,912–75,833,396 108.0 kb Distal (>10kb) Multiome 104
chr17:75,845,103–75,845,662 95.8 kb Distal (>10kb) Multiome 703
chr17:75,854,955–75,856,363 85.6 kb Distal (>10kb) Multiome 1038
chr17:75,877,486–75,878,900 63.1 kb Distal (>10kb) Multiome 884
chr17:75,896,392–75,897,754 44.2 kb Distal (>10kb) Multiome 831
chr17:75,904,371–75,905,532 36.1 kb Distal (>10kb) Multiome 1045
chr17:75,940,734–75,941,471 27 bp At TSS Multiome 982
chr17:75,978,646–75,980,102 38.2 kb Distal (>10kb) Multiome 1090
chr17:75,983,292–75,984,226 42.7 kb Distal (>10kb) Multiome 236
chr17:76,014,120–76,014,727 73.3 kb Distal (>10kb) Multiome 489
chr17:76,029,331–76,030,158 88.5 kb Distal (>10kb) Multiome 722
chr17:76,072,173–76,072,853 131.4 kb Distal (>10kb) Multiome 893
chr17:76,074,414–76,075,796 133.5 kb Distal (>10kb) Multiome 280
chr17:76,103,272–76,104,343 162.6 kb Distal (>10kb) Multiome 798
chr17:76,121,142–76,122,265 180.4 kb Distal (>10kb) Multiome 689
chr17:76,132,004–76,133,216 191.6 kb Distal (>10kb) Multiome 536
chr17:76,135,151–76,135,652 194.1 kb Distal (>10kb) Multiome 104
chr17:76,141,012–76,141,958 200.3 kb Distal (>10kb) Multiome 616
chr17:76,240,278–76,241,169 299.5 kb Distal (>10kb) Multiome 560

Genome Browser

Genomic view of the FBF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:75,656,763 – 76,251,169
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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