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DE-5.15

Submodule 14 genes

DNA repair and RNA splicing regulation

This 14-gene module includes POLH, ESRP1, CNTN1, RNF115, and LNPK, with enriched terms related to DNA repair processes and RNA splicing regulation. Knockdown of ESRP1 represses this module, suggesting a role for this splicing factor in maintaining module expression during endoderm differentiation. No activating transcription factors with strong knockdown effects on this module were identified.

Key terms: regulation of inner ear auditory receptor cell fate specification regulation of inner ear auditory receptor cell differentiation auditory receptor cell fate specification regulation of synapse assembly Notable genes: POLH ESRP1 CNTN1 RNF115 LNPK LMBRD1 CEP70 UACA

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (14)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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