The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FIG4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FIG4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FIG4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:109,440,119–109,441,745 | 250.6 kb | Distal (>10kb) Multiome | 863 | |
| chr6:109,454,912–109,456,586 | 235.4 kb | Distal (>10kb) Multiome | 733 | |
| chr6:109,482,359–109,484,058 | 207.9 kb | Distal (>10kb) Multiome | 675 | |
| chr6:109,678,985–109,679,628 | 12.1 kb | Distal (>10kb) Multiome | 55 | |
| chr6:109,690,198–109,691,786 | 56 bp | At TSS Multiome | 761 | |
| chr6:109,855,571–109,856,389 | 164.6 kb | Distal (>10kb) Multiome | 57 | |
| chr6:109,869,245–109,870,084 | 178.4 kb | Distal (>10kb) Multiome | 41 | |
| chr6:109,944,347–109,945,486 | 253.9 kb | Distal (>10kb) Multiome | 254 | |
| chr6:109,977,901–109,979,311 | 287.2 kb | Distal (>10kb) Multiome | 637 | |
| chr6:110,039,510–110,040,377 | 348.4 kb | Distal (>10kb) Multiome HiCAR | 368 |
Genomic view of the FIG4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.