This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for DDX6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDX6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDX6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:118,530,432–118,531,848 | 260.1 kb | Distal (>10kb) Multiome | 763 | |
| chr11:118,571,906–118,572,919 | 218.8 kb | Distal (>10kb) Multiome | 760 | |
| chr11:118,610,391–118,611,672 | 179.9 kb | Distal (>10kb) Multiome | 488 | |
| chr11:118,620,694–118,621,880 | 169.8 kb | Distal (>10kb) Multiome | 683 | |
| chr11:118,634,418–118,635,567 | 156.1 kb | Distal (>10kb) Multiome | 475 | |
| chr11:118,659,166–118,660,029 | 131.5 kb | Distal (>10kb) Multiome | 459 | |
| chr11:118,689,268–118,690,813 | 101.0 kb | Distal (>10kb) Multiome | 804 | |
| chr11:118,714,768–118,715,435 | 76.3 kb | Distal (>10kb) Multiome | 87 | |
| chr11:118,715,577–118,717,605 | 73.9 kb | Distal (>10kb) Multiome | 445 | |
| chr11:118,789,603–118,790,362 | 1.3 kb | Proximal (<10kb) Multiome | 293 | |
| chr11:118,790,448–118,793,117 | 1.8 kb | Proximal (<10kb) Multiome | 958 | |
| chr11:118,907,074–118,907,685 | 116.1 kb | Distal (>10kb) Multiome | 491 | |
| chr11:118,909,181–118,909,816 | 118.2 kb | Distal (>10kb) Multiome | 326 | |
| chr11:118,909,976–118,911,609 | 119.5 kb | Distal (>10kb) Multiome | 652 | |
| chr11:118,911,717–118,912,963 | 121.1 kb | Distal (>10kb) Multiome | 689 | |
| chr11:118,916,429–118,917,335 | 125.8 kb | Distal (>10kb) Multiome | 355 | |
| chr11:118,917,640–118,918,851 | 127.3 kb | Distal (>10kb) Multiome | 522 | |
| chr11:118,925,703–118,926,356 | 134.9 kb | Distal (>10kb) Multiome | 595 | |
| chr11:118,927,947–118,930,852 | 138.3 kb | Distal (>10kb) Multiome | 892 | |
| chr11:118,997,538–118,998,797 | 206.9 kb | Distal (>10kb) Multiome | 798 | |
| chr11:119,018,081–119,019,265 | 227.4 kb | Distal (>10kb) Multiome | 897 | |
| chr11:119,029,885–119,031,330 | 239.8 kb | Distal (>10kb) Multiome | 876 | |
| chr11:119,056,436–119,057,778 | 266.1 kb | Distal (>10kb) Multiome | 815 | |
| chr11:119,067,446–119,068,100 | 276.6 kb | Distal (>10kb) Multiome | 762 | |
| chr11:119,084,563–119,085,756 | 293.9 kb | Distal (>10kb) Multiome | 846 |
Genomic view of the DDX6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.