DE-5

DE-5.5

Submodule 23 genes

Signal transduction and vesicular trafficking functions

This module contains 23 genes including STAT6, BBS1, SLC35A1, TOM1L1, and MSTO1, with top enriched terms related to signal transduction and intracellular transport. Knockdown of ZC3H3 represses this module, suggesting ZC3H3 positively regulates these genes during endoderm differentiation.

Notable genes: STAT6 BBS1 SLC35A1 TOM1L1 MSTO1 IFT81 ERV3-1 AMZ2 Top TFs: ZC3H3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (21)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z