Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in regulation of RNA splicing. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCNL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:155,980,533–155,981,958 | 1179.1 kb | Distal (>10kb) Multiome HiCAR | 149 | |
| chr3:156,897,559–156,898,592 | 262.1 kb | Distal (>10kb) Multiome | 147 | |
| chr3:157,108,708–157,110,262 | 50.5 kb | Distal (>10kb) Multiome | 379 | |
| chr3:157,129,802–157,131,179 | 29.6 kb | Distal (>10kb) Multiome | 724 | |
| chr3:157,142,157–157,142,920 | 17.6 kb | Distal (>10kb) Multiome | 171 | |
| chr3:157,159,206–157,161,193 | 41 bp | At TSS Multiome | 1215 | |
| chr3:157,162,679–157,163,081 | 2.5 kb | Proximal (<10kb) | 25 | |
| chr3:157,174,174–157,175,938 | 14.8 kb | Distal (>10kb) Multiome | 1138 | |
| chr3:157,347,437–157,348,263 | 187.7 kb | Distal (>10kb) Multiome | 150 | |
| chr3:157,437,270–157,438,724 | 277.7 kb | Distal (>10kb) Multiome | 510 | |
| chr3:157,499,252–157,500,077 | 339.4 kb | Distal (>10kb) Multiome HiCAR | 427 |
Genomic view of the CCNL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.