The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for SOAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:179,002,311–179,003,353 | 291.0 kb | Distal (>10kb) Multiome | 522 | |
| chr1:179,025,292–179,027,102 | 267.8 kb | Distal (>10kb) Multiome | 930 | |
| chr1:179,081,467–179,083,301 | 211.8 kb | Distal (>10kb) Multiome | 968 | |
| chr1:179,087,385–179,088,206 | 206.0 kb | Distal (>10kb) Multiome | 194 | |
| chr1:179,228,751–179,230,142 | 64.1 kb | Distal (>10kb) Multiome | 634 | |
| chr1:179,291,423–179,291,999 | 1.8 kb | Proximal (<10kb) | 17 | |
| chr1:179,293,131–179,294,199 | 37 bp | At TSS Multiome | 884 | |
| chr1:179,365,435–179,366,459 | 72.1 kb | Distal (>10kb) Multiome | 811 | |
| chr1:179,586,188–179,586,937 | 292.7 kb | Distal (>10kb) Multiome | 413 | |
| chr1:179,591,348–179,592,445 | 298.1 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the SOAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.