This 18-gene module includes SCN8A, JAM3, GALNT3, RGS17, and GNB5, with top enriched terms related to ion transport, G-protein signaling, and cell adhesion. Knockdown of SOX17 activates this module, while knockdown of EOMES and GATA4 represses it. These regulatory patterns suggest the module represents a differentiation-associated gene set responsive to endoderm transcription factors.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.